Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC+LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, L63I, H69K, L89M, I93L |
| >12ZAKS264| codons 39-99 PGKWKPKMIGGIGGFIKVRQYDQIIIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLN F |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, V60I, D121C, K122E, K173A, D177E, I178L, I195L, T200A, Q207N, R211K, V245I, A272P, T286A, E291D, V292I, I293V, P313T, Q334H, G335D, R356K, M357R, G359T, A376S, T377M, K390R, A400T, E404D |
| >12ZAKS264| codons 1-419 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL CEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPELVI YQYMDDLYVGSDLELGQHRAKIEELRNHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKETVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVKQLTEAVQKISMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNT |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |