Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 10ZAKS072 | 10ZAKS072 | South Africa | 2010 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+LPV | NA |
| 2 | 3TC+D4T+LPV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K101E | E138K | P4S, E6K, K11S, K20R, V35T, E36A, T39E, S48T, V90I, K122E, D123G, S162A, T165I, K173T, Q174K, D177DE, I178IM, V179A, T200A, I202IV, Q207E, R211K, F214L, V245Q, E248D, D250DE, A272P, K277KR, L283I, E291D, V292I |
| >10ZAKS072| codons 1-324 PISSIKTVPVSLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNKTPGIRYQYNVLPQGWKGSPAIFQASMIKILEPFRTKNPEMAI YQYMDDLYVGSDLEIGQHRAKVEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTDIIPLTEEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, L63S, H69K, I93L |
| >10ZAKS072| codons 39-99 PGKWKPKMIGGIGGFIKVRQYDQISIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLN F |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |