Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, Q151M, M184V | A62V, V75I, F116Y | V106M, G190A | F227L | V35T, T39E, S68G, T69I, K102E, K122E, K173T, D177E, I178L, V179I, T200A, I202V, Q207DE, R211RK, F214L, V245K, A272P, R284K, T286A, E291D, V292I, I293V, E297K, Q334D, G335D, R356K, M357R, G359T, V365I, K366R, T377M, K385KR, K390R, A400T, E404D, I434M, V435T |
| >11ZAKS095| codons 1-438 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKISKIGPENPYNTPV FVIKKKDGIKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKEKKSMTVLDVGDAYYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRTQNPELII YQYVDDLYVASDLEIGQHRAKVEELREHLLKWGLTTPDKKHQKEPPLLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTDIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDIRQLTEAVQKIAMESIVIWGRTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPMTGAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, H69K, I72IM, L89M, I93L |
| >11ZAKS095| codons 39-99 PGKWKPKMIGGIGGFIKVRQYDQILIEICGKKAMGTVLVGPTPVNIIGRNMLTQLGCTLN F |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |