<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12ZAKS297 12ZAKS297 South Africa 2012 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   V106M F227L V35T, E36A, T39E, S48T, V60I, K122E, I132V, K173A, Q174K, D177E, T200A, Q207E, H221Y, K238R, V245E, A272S, T286A, E291D, V292I, E297K, K311R, V314A, D324E, Q334D, G335D, R356K, M357R, G359T, A371V, T377L, K390R, A400I, E404D  
>12ZAKS297| codons 1-421
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSVPL
DEDFRKYTAFTVPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKYQKEPPLLWMGYELHPDRWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIIPLTKEAE
LELAENREILREPAHGVYYDPSKELIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEVVQKIALESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP
P

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    R41K, H69K, T74S, L89M, I93L  
>12ZAKS297| codons 39-99
PGKWKPKMIGGIGGFIKVRQYDQILIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLN
F

References
Author Title Citation
Steegen, K High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. PLoS ONE, 2014