<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+LPV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I50IV, I54V, V82A   R41K, H69K, A71V, T74S, L89I, I93L  
>11ZAKS165| codons 39-99
PGKWKPKMIGGVGGFVKVRQYDQILIEICGKKVIGSVLVGPTPANIIGRNILTQLGCTLN
F

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       V35T, E36A, T39E, S48T, D121H, K122E, I135T, T165I, D177E, T200E, Q207A, R211K, V245K, E248D, D250E, A272P, K281R, E291D, V292I, I293V, E297T, E308K, V317A, Q334H, G335D  
>11ZAKS165| codons 1-350
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIGQHREKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTDIVPLTTEAE
LELAENRKILKEPVHGAYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLK

References
Author Title Citation
Steegen, K High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. PLoS ONE, 2014