Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12ZAKS360 | 12ZAKS360 | South Africa | 2012 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+RTV+SQV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N | P4S, K20R, V35T, E36A, T39D, A98AS, I135L, E138Q, S162A, K173T, T200A, Q207E, R211K, D250E, K277KR, K281KR, E291D, V292I, I293V, H315Y, V317A, I329L, Q334N, G335D, R356K, G359T, T377L, K390R, A400T, E404D | I270S |
| >12ZAKS360| codons 1-433 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICDEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNQTPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQSYAGIKVRQLCRLLRGTKALTDIVPLTEEAE LELAENREILKEPVYGAYYDPSKDLIAELQKQGNDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, D60E, H69K, L89M, I93L |
| >12ZAKS360| codons 39-99 PGKWKPKMIGGIGGFIKVRQYEQILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLN F |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |