Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1848 | 4675-1 | U.S. | 1998 | HIV1 | B | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC | 56 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, L210W, T215Y | K219R | E28K, K32E, R83K, K122E, S162Y, E169D, D177E, I178L, R211K, A272P | R284RS |
| >4675-1| codons 1-328 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRKQNPELVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLSGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAE |
References
| Author | Title | Citation |
| Gonzales, MJ | Colinearity of reverse transcriptase inhibitor resistance mutations detected by population-based sequencing. | JAIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |