Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1170 | CA2657 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 17 |
| 2 | 3TC+AZT+IDV | 61 |
| 3 | 3TC+D4T+IDV | 30 |
| 4 | 3TC+DDC+NFV | 13 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | T215V, K219E | T69N, I135T, T200A, Q207E |
| >CA2657| codons 1-255 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFVTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVN |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | L10F, N88T | K14R, N37S, R41K, I62V, L63P, V77I, I93L |
| >CA2658| codons 1-99 PQITLWQRPFVTIRIGGQLKEALLDTGADDTVLEEMSLPGKWKPKIIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRTLLTQLGCTLNF |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |