<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1166 CA2650 U.S. 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 34
2 DDC 21
3 D4T 21
4 3TC+ AZT 35
5 AZT+ D4T 17
6 AZT+ D4T+ IDV 13
7 3TC+ D4T+ IDV 47
8 3TC+ D4T+ NFV 24

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   I15L, L19I, K20R, R41K, L63A, A71V, I93L  
>CA2650| codons 1-99
PQITLWQRPLVTIKLGGQIREALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD
QIAIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, K70R, Y115F, Q151M V75I, F77L, F116Y, K219KE     E6D, V35IM, S68G, K122E, I135T, T200I, I202V, V245M, A272P, K275KR, E297D T216TI
>CA2649| codons 1-299
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FAIKRKDGTRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRIKVEELRQHLLRWGFTIPDEKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVIPLTDEA

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005