Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1166 | CA2649 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 34 |
| 2 | DDC | 21 |
| 3 | D4T | 21 |
| 4 | 3TC+ AZT | 35 |
| 5 | AZT+ D4T | 17 |
| 6 | AZT+ D4T+ IDV | 13 |
| 7 | 3TC+ D4T+ IDV | 47 |
| 8 | 3TC+ D4T+ NFV | 24 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Y115F, Q151M | V75I, F77L, F116Y, K219KE | E6D, V35IM, S68G, K122E, I135T, T200I, I202V, V245M, A272P, K275KR, E297D | T216TI |
| >CA2649| codons 1-299 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKRKDGTRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRIKVEELRQHLLRWGFTIPDEKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVIPLTDEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | I15L, L19I, K20R, R41K, L63A, A71V, I93L |
| >CA2650| codons 1-99 PQITLWQRPLVTIKLGGQIREALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIAIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |