Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1158 | CA2634 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 42 |
| 2 | AZT+DDI | 10 |
| 3 | 3TC+AZT+IDV | 44 |
| 4 | AZT+IDV+NVP | 9 |
| 5 | 3TC+AZT+NFV+SQV | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | F53FL | L10I, E35D, M36V, R57K, D60E, I62V, L63P, A71V, I93L |
| >CA2634| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDVNLPGRWKPKMIGGIGGLVKVKQYE QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | V75L | K43N, K122E, E138A, I142V, S162C, R172X, V179VA, I180X, T200X, R211Q, L228R | L168LF |
| >CA2633| codons 1-243 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGVRYQYNVLPQGWKGSPAIFQCSMTKIFEPFXKQNPDIAX YQYVDDLYVGSDLEIGQHRXKIEELRQHLWQWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQP |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |