Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 452356_2 | 452356_2 | South Africa | 2010 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+EFV+TDF | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K70Q | Y181C, G190A | V35M, E36A, T39E, K46Q, S48T, K122E, D123N, T139K, K173V, Q174K, T200A, Q207K, R211K, V245Q, D250E |
| >452356_2| codons 1-255 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMAICEEMEKEGQITKIGPENPYNTPV FAIKKKDSTQWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRVKNPDIVI CQYVDDLYVASDLEIGQHRAKIEELRKHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVN |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, Q18E, L19I, M36I, R41K, D60E, Q61E, L63S, H69K, L89M, I93L |
| >452356_2| codons 1-99 PQITLWQRPLVTIKVGGEIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE EISIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Hoffmann, CJ | Resistance to tenofovir-based regimens during treatment failure of subtype C HIV-1 in South Africa. | Antivir Ther, 2013 |
| Rhee, SY | Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration. | EBioMedicine, 2017 |