Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1144 | CA2602 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI | 57 |
| 3 | AZT+DDI | 8 |
| 4 | AZT+DDC | 35 |
| 5 | 3TC+D4T | 13 |
| 6 | AZT+D4T+RTV+SQV | 57 |
| 7 | AZT+D4T+RTV+SQV | 27 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, L90M | Q58E | L10I, K14R, M46X, Q61E, I62V, L63P, A71V, V77I, I93L |
| >CA2602| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKXIVGIGGFVKVREYD EVPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | V35M, T69N, V118I, K122E, I135T, I202V, F214L |
| >CA2601| codons 1-253 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWT |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |