Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | LPV+NNRTI+NRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, L90M | L33F, N83D | L10V, I13V, K20R, E35DN, M36I, N37E, P39Q, R41K, D60E, Q61E, H69K, L89IM |
| >LL0499| codons 1-99 PQITLWQRPVVTVKIGGQLREALLDTGADDTVFENIELQGKWKPKLIVGIGGFIKVRQYE EILIEICGKKAIGTVLVGPTPVDIIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | D67G, K219Q | Y181C | K11T, K20R, V35T, T39S, V60I, T69N, D121Y, K122E, I135T, T139R, E169D, K173A, Q174K, D177E, V179I, G196E, T200A, E203V, Q207A, R211K, F214L, L228H, Q242H, D250E, A272P, L283I, E291D, I293V, E312D, Q334E |
| >LL0499| codons 1-335 PISPIETVPVTLKPGMDGPRVKQWPLTEEKIKALTEICSEMEKEGKISKIGPENPYNTPI FAIKKKGSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNERPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPEIII CQYVDDLYVGSDLEIEQHRAKIVELRAHLLKWGLTTPDQKHQKEPPFHWMGYELHPDKWT VHPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTDVVPLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGEG |
References
| Author | Title | Citation |
| Rawizza, HE | Accumulation of protease mutations among patients failing second-line antiretroviral therapy and response to salvage therapy in Nigeria. | PLoS ONE, 2013 |