Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LN4321 | LN4321 | Nigeria | 2009 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | LPV+NNRTI+NRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M, M184V | A62V, V75I, F77L, F116Y, K219E | Y181C | K20R, V35T, S68G, T69I, I135V, S162A, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245E, S251H, T286A, E291D, V292I, I293V, P294T, E297K, K311R, S322T, I326V |
| >LN4321| codons 1-334 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FVIKRKDGIKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSPAIFQASMTKILEPFRTKNPELVI CQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDEKHQKEPPFLWMGYELHPDKWT VQPIELPEKDHWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTKEAE LELAENREILREPVHGVYYDPTKDLVAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F | Q58E, N83D | L10V, T12M, I13A, K14KR, G16A, L19P, K20I, A22V, E35N, M36I, N37D, R41RK, Q61QH, L63P, H69K, A71V, L89I, I93M |
| >LN4321| codons 1-99 PQITLWQRPVVMARIAGQPIEVLLDTGADDTVLENIDLPGKWKPKMIGGIGGFVKVREYD HIPIEICGKKVIGTVLVGPTPFDIIGRNILTQMGCTLNF |
References
| Author | Title | Citation |
| Rawizza, HE | Accumulation of protease mutations among patients failing second-line antiretroviral therapy and response to salvage therapy in Nigeria. | PLoS ONE, 2013 |