<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TH_215 TH_215 Thailand 2002 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 NFV+ AZT+ DDI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215F K219Q     V35T, T39K, K43E, K104N, D121H, K122E, D123S, I135V, S162A, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E  
>TH_215| codons 21-255
VKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPLHESFRKYTAFTIPSVNNETP
GIRYQYNVLPQGWKGSPAIFQASMTKILEPFRIKNPEMVIYQYMDDLYVGSDLEIGQHRI
KIEELRAHLLSWGFFTPDQKHQKEPPFLWMGYELHPDRWTVQPIELPEKDSWTVN

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
N88S, L90M L10F I13V, I15V, K20T, E35D, M36I, R41K, I64V, H69K, L89M  
>TH_215| codons 1-95
PQITLWQRPFVTVKVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILVEICGKKAIGTVLVGPTPVNIIGRSMMTQIGC

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005