Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1127 | CA2537 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 157 |
| 2 | DDI | 4 |
| 3 | AZT+DDC | 52 |
| 4 | 3TC+AZT | 56 |
| 5 | 3TC+D4T+SQV | 22 |
| 6 | 3TC+D4T+IDV | 26 |
| 7 | 3TC+D4T+RTV+SQV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, M36I, N37D, R41RK, L63P, I64L, A71V, I93L |
| >CA2537| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEIDLPGKWKPKMIVGIGGFTKVRQYD QIPLEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | K20R, T69N, K102R, K122P, I135V, D177E, V179I, G196E, F214FL, V245T |
| >CA2536| codons 1-261 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLV |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |