<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
IL257 IL257 Israel 2001 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 RTV+ IDV+ 3TC+ AZT 110

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82A   L10I, I15V, L19I, M36I, R41K, L63P, H69K, I85V, I93L D29DV
>IL257| codons 4-99
TLWQRPIVTIKVGGQIKEALLDTGAVDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQIP
IEICGKKAIGTVLVGPTPANIVGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       T39E, K122E, D123G, I135T, S162C, K173A, Q174K, D177EG, Q197H, T200A, Q207E, R211K, V245Q P52PL, N57NK, F61FL
>IL257| codons 37-247
ICEEMEKEGKISKIGLENPYKTPVLAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPH
PAGLKKKKSVTVLDVGDAYFSVPLDEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGS
PAIFQCSMTKILEPFRAKNPEIVIYQYVDDLYVGSDLEIGHHRAKIEELREHLLKWGFTT
PDKKHQKEPPFLWMGYELHPDKWTVQPIQLP

References
Author Title Citation
Grossman, Z Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005