Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CAS043 | CAS043 | South Africa | 2011 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+EFV+TDF | 26 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN, M184I | Y181C | V108I, V179E | K20R, V35T, E36A, T39K, K43E, S48T, V60I, V90VI, K102Q, K103R, K122E, D123N, Q174K, D177E, V189VI, T200A, R211K, F214L, H221HY, V245Q, A272P, A288S, E291D, V292I, I293V |
| >CAS043| codons 1-333 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICKEMEEEGKITKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKQRKSVTILDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEIEI CQYIDDLYIGSDLEIGQHRAKIEELRQHLLKWGLTTPDKKYQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, E35D, M36I, R41K, K45R, L63P, H69K, L89M, I93L |
| >CAS043| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Sunpath, H | High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen. | AIDS, 2013 |