Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CAS090 | CAS090 | South Africa | 2010 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+EFV+TDF | 26 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | L100I, K103N, V106M | V35T, T39E, E40Q, S48T, K122E, D123N, I135M, T139A, S162C, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, E297A |
| >CAS090| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEQMEKEGKITKIGPENPYNTPV FAIKRKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSMTVLDVGDAYFSVPL DENFRKYTAFTIPSMNNEAPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPELVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, I15V, G17D, L19I, M36I, R41K, H69K, L89M, I93L |
| >CAS090| codons 1-99 PQITLWQRPLVTIRVGDQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Sunpath, H | High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen. | AIDS, 2013 |
| Rhee, SY | Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration. | EBioMedicine, 2017 |