<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 26

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K65R, L74V, Y115F V75T G190E   K20R, V35T, T39E, S48T, V60I, S68G, D121H, K122E, I135V, I142V, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, H221Y, V245Q, A272P, K275R, V276T, E291D, V292I, I293V, I329V  
>CAS033| codons 1-333
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEELEKEGKITKIGPENPYNTPI
FAIKRKDGTKWRKVTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL
HEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI
YQYMDDLYVESDLEIGQHRAKIEELREHLLKWGLTTPDKKYQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIRTKQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, L19E, M36I, R41K, Q61N, L63A, E65D, H69K, I93L  
>CAS033| codons 13-99
IKVGGQEKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDNIAIDICGKKAI
GTVLVGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Sunpath, H High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen. AIDS, 2013