Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4001 | CA24837 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 95 |
| 2 | 3TC+AZT | 8 |
| 3 | 3TC+AZT+IDV | 65 |
| 4 | D4T+DDI+NFV | 99 |
| 5 | ABC+IDV+NVP+RTV | 8 |
| 6 | D4T+DDI+IDV+RTV | 74 |
| 7 | 3TC+LPV+NVP | 19 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | Q58E, G73S | L10I, K20R, E35D, M36I, N37D, K55R, I62V, L63P, A71V, I72IL |
| >CA24837| codons 1-98 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVRVREYD QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75T, M184MIV, T215F | K219Q | Y181C | V108I | K20KR, T39N, K104Q, V118I, K122P, I135IT, T139TK, I142V, K166R, D177E, F214L, L228LH, T286TA, I293V, E297K |
| >CA24836| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTILDVGDAYFSIPL DPDFRKYTAFTIPSTNNEKPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTKEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |