Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5996 | CA24827 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | DDI | 47 |
| 3 | DDC | 43 |
| 4 | AZT+ 3TC | 25 |
| 5 | AZT+ 3TC+ IDV | 30 |
| 6 | RTV+ AZT+ 3TC | 60 |
| 7 | AZT+ 3TC+ NFV | 26 |
| 8 | 3TC+ AZT+ NFV+ SQV | 21 |
| 9 | D4T+ 3TC+ NFV+ SQV | 36 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GV, I84V, L90M | G73GS | L10I, I13V, E34D, E35ED, M36V, N37S, L63P, A71V, T74TS, I93IL |
| >CA24827| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLDDVSLPGRWKPKMIVGIGGFIKVRQYD QIPIEICGHKVISSVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215F | V75VA, K219Q | V35M, K122E, I135L, I178IM, T200A, E203K, Q207E, L228H, E248V |
| >CA24826| codons 1-249 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLADFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRAKIKELREHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPVK |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |