Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1426 | CA24807 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 34 |
| 2 | AZT+ D4T+ SQV | 30 |
| 3 | 3TC+ D4T+ IDV | 82 |
| 4 | D4T+ DDC+ NFV | 28 |
| 5 | RTV+ SQV+ DDI | 8 |
| 6 | RTV+ SQV+ DDC | 24 |
| 7 | D4T+EFV+IDV | 52 |
| 8 | ABC+APV+DDI+NVP | 68 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V | V11VI, G73GS, L89V | L10I, K20I, N37A, R41K, L63P, A71V, V77I, I85V, I93L |
| >CA24807| codons 1-98 PQITLWQRPIITIKIGGQLIEALLDTGADDTVLEEMALPGKWKPKIIGGIGGFMKVRQYD QIPIEICGHKVISTVLIGPTPVNVVGRNVLTQLGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74V, Y115F, Q151M | K70S, K219Q | Y181C, G190S | V35VI, V60I, T69N, V90I, K101Q, K122E, D123DN, I135V, R172K, G196E, F214FL, D218E, H221HY, V245T, K277R, T286A, I293V, E297K |
| >CA24806| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNSWRKVVDFRELNKRTQDFWEIQLGIPHPAGLQKKKSVTVLDVGDAFFSVPL DENFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIVI CQYMDDLYVSSDLEIEQHRTKIEELRQHLLRWGLTTPEQKYQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |