Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1426 | CA24805 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 34 |
| 2 | AZT+ D4T+ SQV | 30 |
| 3 | 3TC+ D4T+ IDV | 82 |
| 4 | D4T+ DDC+ NFV | 28 |
| 5 | RTV+ SQV+ DDI | 8 |
| 6 | RTV+ SQV+ DDC | 24 |
| 7 | D4T+EFV+IDV | 45 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V | G73S | L10I, K20I, N37A, R41K, I62V, L63P, A71V, V77I, I93L |
| >CA24805| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEMALPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219Q | K101PQ, G190S | K11KR, E28G, V60I, T69N, V90VI, K122E, I135V, G196E, D218E, V245T, K277R, T286A, I293V, E297K |
| >CA24804| codons 1-302 PISPIETVPVRLKPGMDGPKVKQWPLTGEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLPKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIEQHRTKIEELRQHLLRWGFTTPEQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE LE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |