<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1426 CA24804 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 35
2 AZT+D4T+SQV 30
3 3TC+D4T+IDV 83
4 D4T+DDC+NFV 29
5 DDI+RTV+SQV 8
6 DDC+RTV+SQV 24
7 D4T+EFV+IDV 45

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R K219Q K101PQ, G190S   K11KR, E28G, V60I, T69N, V90VI, K122E, I135V, G196E, D218E, V245T, K277R, T286A, I293V, E297K  
>CA24804| codons 1-302
PISPIETVPVRLKPGMDGPKVKQWPLTGEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLPKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIEQHRTKIEELRQHLLRWGFTTPEQKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE
LE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V G73S L10I, K20I, N37A, R41K, I62V, L63P, A71V, V77I, I93L  
>CA24805| codons 1-99
PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEMALPGKWKPKMIGGIGGFIKVRQYD
QVPIEICGHKVISTVLIGPTPVNVIGRNLLTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005