Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1833 | CA24787 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 44 |
| 2 | D4T | 87 |
| 3 | 3TC+AZT+IDV | 42 |
| 4 | 3TC+D4T+IDV | 26 |
| 5 | DDC+NFV+NVP | 47 |
| 6 | DDC+RTV+SQV | 31 |
| 7 | ABC+EFV+RTV+SQV | 38 |
| 8 | APV+D4T+EFV+RTV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54M, V82A, I84V | L33F | L10I, T12S, L19V, L63T, A71V, I72T, I93L |
| >CA24787| codons 1-99 PQITLWQRPIVSIKIGGQVKEALLDTGADDTVFEEMNLPGRWKPKLIVGIGGFMKVRQYD QITIEICGHKVTGTVLVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, L210W, T215Y | K101E, Y181C, G190A | A98G | K20R, T39E, E44D, V118I, K122E, I135T, G196E, E203K, R211K, A272S, V276T, K277R, Q278E, L283I, I293V, E297KR, L303T | E302R |
| >CA24786| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIEQHRTKIKELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKTRELCKLIRGTKALTEVVPLTKEAE LRT |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |