Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA639 | CA24751 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+ DDC | 13 |
| 3 | AZT+ DDI | 34 |
| 4 | 3TC+ AZT | 21 |
| 5 | 3TC+ AZT+ D4T | 13 |
| 6 | 3TC+ AZT+ SQV | 17 |
| 7 | 3TC+ D4T+ IDV | 69 |
| 8 | Unknown | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48V, I54T, V82A | K43T | L10I, G16A, K20R, E35D, M36I, L63P, A71V, I93L |
| >CA24751| codons 1-99 PQITLWQRPIVTIKIAGQLREALLDTGADDTVLEDINLPGRWTPKIIVGIGGFTKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, M184V, L210W, T215Y | E44ED, K104KN, V118VI, D121DY, K122E, I135V, S162CG, K166KN, T200A, Q207QE, R211K, A272P, K277R |
| >CA24750| codons 1-277 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTNILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVR |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |