Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1866 | CA24677 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 64 |
| 2 | AZT+DDC | 17 |
| 3 | AZT | 34 |
| 4 | AZT+IDV | 17 |
| 5 | IDV+DDI | 39 |
| 6 | 3TC+D4T+NVP | 58 |
| 7 | D4T+IDV+RTV | 29 |
| 8 | D4T+IDV+3TC+RTV | 121 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73T | L10I, K20I, K55R, R57K, L63P, A71IV, I72E, I93L |
| >CA24677| codons 1-98 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVKQYD QIPIEICGHKVETTVLVGPTPVNVIGRNLMTQLGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K43N, E44D, W88C, V118I, K122E, G196E, E203K, Q207E, R211K, A272P, V276T, E297K, I309L, I329V, G333D, Q334N, G359S, A360T, A371V, E399D, A400T, V435A, D460N, R461K, V467I, L469V, H483Y, L491S, Q524E |
| >CA24676| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTKQLCKLLRGTKALTEVIPLTKEAE LELAENRELLKEPVHGVYYDPSKDLIAEVQKQDNGQWTYQIYQEPFKNLKTGKYARMRST HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWDTWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTNKGRQKVISVTDTTNQKTELQ AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEELIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |