Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5205 | CA24665 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+IDV | 45 |
| 2 | D4T+IDV+NVP | 77 |
| 3 | ABC+AZT+NFV | 19 |
| 4 | ABC+DDC+NFV | 8 |
| 5 | ABC+DDI+RTV+SQV | 103 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S, L90M | Q58QE | L10I, I13V, K20I, L63P, A71T, I93L |
| >CA24665| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QIPIEICGHKTIGTVLVGPTPVNIIGRSLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, M184V, T215Y | K219E | K101E, Y181C, G190A | K20R, T165I, T200A, R211K, V245VE, K275Q, K277R, T286A, E291D, E302D |
| >CA24664| codons 1-302 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRAKIEELRQHLLKWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIQVRQLCKLLRGAKALTDVIPLTEEAE LD |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |