Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1468 | CA24655 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 178 |
| 2 | 3TC+Unknown | 122 |
| 3 | NVP+Unknown | 31 |
| 4 | 3TC+D4T+DDI+RTV+SQV | 4 |
| 5 | 3TC+DDI+RTV+SQV | 26 |
| 6 | 3TC+D4T+DDI+RTV+SQV | 5 |
| 7 | 3TC+D4T+RTV+SQV | 60 |
| 8 | 3TC+APV+D4T | 31 |
| 9 | 3TC+D4T+LPV+NVP | 42 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LI, M184V, L210W, T215Y | Y181C | V108I | V21I, T69S, R83K, T139M, S162A, D177E, R211K | V254VD |
| >CA24655| codons 1-256 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKIVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTDND |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, R20RK, E87ED, T124A, T125A, V150VI, K173R, K211Q |
| >CA158560| codons 1-288 FLDGIDKAQEEHEKYHNNWKAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEADVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN FTSAAVKAACWWAGIKQEFGIPYNPQSQGIVESMNKELKKIIGQVRDQAEHLRTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTQELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |