Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA9956 | CA24644 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 13 |
| 2 | DDI | 30 |
| 3 | 3TC+D4T | 48 |
| 4 | 3TC+D4T+DDC+NFV | 13 |
| 5 | 3TC+AZT+NVP | 13 |
| 6 | 3TC+AZT+SQV | 192 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, L90M | E35D, M36I, N37ND, L38LW, R41K, L63P, I64V, T74S, I93L |
| >CA24644| codons 13-99 IKIGGQLKEALLDTGADDTVLEDIDWPGKWKPKMIVGIGGFIKVRQYDQIPVEICGHKAI GSVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | D121DE, K122P, I135L, Q174QH, V179VI, R211K, F214L, A272P, V276VI, K277R, T286A, P294Q, E297K |
| >CA24643| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL EPDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIII YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIRQLCKLLRGAKALTEVIQLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |