Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5052 | CA24634 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 82 |
| 2 | DDC+ AZT | 56 |
| 3 | DDI | 39 |
| 4 | RTV+ D4T+ 3TC | 30 |
| 5 | IDV+ D4T+ 3TC | 34 |
| 6 | None | 124 |
| 7 | NFV+ AZT+ 3TC | 32 |
| 8 | EFV+ AZT+ 3TC | 17 |
| 9 | TDF+ LPV+ DDI+ 3TC | 42 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | K20R, M36I, R41K, D60E, I62V, L63P, A71V, I93L |
| >CA24634| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVRQYE QVPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215F | G190Q | V35VL, K43Q, V118I, K122P, V189I, R211EG, L228R, A272P, P294T, E297K |
| >CA24633| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYIQSDLEIGQHRTKIEELRQHLWEWGFFTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVITLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |