Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5016 | CA24594 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 39 |
| 2 | DDI | 22 |
| 3 | D4T+IDV | 30 |
| 4 | 3TC+DDI+NFV | 48 |
| 5 | D4T+DDI+NVP | 84 |
| 6 | 3TC+AZT+DDI+EFV | 104 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | M36I, R57K, I62V, L63S, A71V, I93L |
| >CA24594| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVKQYD QVSIEICGHKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V | K101KE, K103KN, Y181C, G190A | V108I | E6D, I31IL, A98S, K102Q, K122E, I135V, S162T, E169D, T200I, T215X, H221Y, D237E, K277R, T286A, E291D, E297A |
| >CA24593| codons 1-300 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKLKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLEQNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQTSMTKILDPFRKQNPDIVI CQYVDDLYVASDLEIGQHRIKIEELRQHLLRWGFXTPDKKYQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDVIPLTAEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |