Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2105 | CA24588 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 69 |
| 2 | D4T | 22 |
| 3 | AZT | 11 |
| 4 | AZT+ 3TC | 12 |
| 5 | AZT+ 3TC+ IDV | 50 |
| 6 | DDI+ D4T+ NFV | 58 |
| 7 | D4T+ DLV+ NFV | 33 |
| 8 | D4T+ RTV+ SQV | 55 |
| 9 | APV+D4T+SQV | 86 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IV, V82VA, I84IV, L90M | T12S, L19I, L24LF, R57K, L63P, A71I, V77I, I93L |
| >CA24588| codons 1-99 PQITLWQRPLVSIKIGGQIKEALFDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVKQYD QIPIEICGHKIIGTVLIGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215F | K103N | V35L, T39K, K43E, I135L, S162C, R211K, A272S, I293V |
| >CA24587| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICKELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |