Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA794 | CA24578 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | DDI | 43 |
| 3 | DDC | 13 |
| 4 | D4T | 30 |
| 5 | AZT+D4T | 18 |
| 6 | 3TC+AZT+IDV | 52 |
| 7 | D4T+DDI+NVP | 19 |
| 8 | 3TC+D4T+RTV+SQV | 58 |
| 9 | 3TC+DDI+EFV+RTV+SQV | 17 |
| 10 | 3TC+RTV+SQV | 45 |
| 11 | None | 34 |
| 12 | ABC+DDI+LPV | 11 |
| 13 | ABC+APV+DDI+LPV | 17 |
| 14 | ABC+DDI+LPV | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L10F, L33F, K43T | K20R, E35D, M36V, N37D, D60E, I62V, L63P, A71V, I93L |
| >CA24578| codons 1-98 PQITLWQRPFVTIKIGGQLREALLDTGADDTVFEDVDLPGRWTPKLIGGIGGFVKVRQYE QVPIEICGHKVIGTVLVGPTPANVIGRNLMTQLGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, D67N, Q151M, L210W, T215Y | A62V, V75I, F116Y | Y181I | K20R, V21I, V35I, K43Q, S68N, E79D, R83K, K122E, G196E, Q197K, F214L, K223Q, A272P, K277R |
| >CA24577| codons 1-299 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FVIKRKNNTKWRKLIDFRDLNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI IQYMDDLYVGSDLEIEKHRTKIEELRQHLWRWGLYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEA |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |