<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA7978 CA24574 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT 21
2 SQV+ AZT+ 3TC 4
3 RTV+ AZT+ 3TC 4
4 IDV+ AZT+ 3TC 21
5 IDV+ DDI+ D4T 43
6 SQV+ RTV+ DDI+ D4T 80
7 EFV+ D4T+ APV+ 3TC 128

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54L, V82T, L90M G73S, L89V L10I, N37ND, R41RK, I62V, L63P, A71V, I85V, I93L, T96TS  
>CA24574| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGKWKPKLIGGIGGFLKVRQYD
QVPIEICGHKVISTVLVGPTPTNIVGRNVMTQLGCSLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y   G190Q A98G K43E, V60I, R83RK, I94IL, V118I, K122E, I135V, I178L, T200A, R211K, V245E, A272P, K277R, I293V, E297R  
>CA24573| codons 1-302
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKKTQDFWEVQLGLPHPGGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYVDDLYVQSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE
LE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005