Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7978 | CA24573 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 21 |
| 2 | SQV+ AZT+ 3TC | 4 |
| 3 | RTV+ AZT+ 3TC | 4 |
| 4 | IDV+ AZT+ 3TC | 21 |
| 5 | IDV+ DDI+ D4T | 43 |
| 6 | SQV+ RTV+ DDI+ D4T | 80 |
| 7 | EFV+ D4T+ APV+ 3TC | 128 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | G190Q | A98G | K43E, V60I, R83RK, I94IL, V118I, K122E, I135V, I178L, T200A, R211K, V245E, A272P, K277R, I293V, E297R |
| >CA24573| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKKTQDFWEVQLGLPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYVQSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82T, L90M | G73S, L89V | L10I, N37ND, R41RK, I62V, L63P, A71V, I85V, I93L, T96TS |
| >CA24574| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGKWKPKLIGGIGGFLKVRQYD QVPIEICGHKVISTVLVGPTPTNIVGRNVMTQLGCSLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |