Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4305 | CA24552 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 218 |
| 2 | 3TC+AZT | 22 |
| 3 | 3TC+AZT+RTV | 61 |
| 4 | 3TC+AZT+NVP | 48 |
| 5 | D4T+DDC+NFV | 48 |
| 6 | 3TC+D4T+EFV+IDV | 101 |
| 7 | D4T+DDI+SQV | 19 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | N88D | I15V, E35D, M36I, N37D, L63P, A71V, V75I |
| >CA24552| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVIGTILVGPTPANIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, T69S_VG, M184I | A62AV | Y181C, G190A | K101H, V108I, E138EK | E6K, M16MV, K64R, K122E, I135V, Y144F, E204D, H221Y, I293V, E297K |
| >CA24551| codons 1-301 PISPIKTVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIRKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSVNNKTPGIRFQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYIDDLYVASDLEIGQHRTKIEDLRQHLLRWGFTTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE L |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |