<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4305 CA24551 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 218
2 3TC+AZT 22
3 3TC+AZT+RTV 61
4 3TC+AZT+NVP 48
5 D4T+DDC+NFV 48
6 3TC+D4T+EFV+IDV 101
7 D4T+DDI+SQV 19

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, T69S_VG, M184I A62AV Y181C, G190A K101H, V108I, E138EK E6K, M16MV, K64R, K122E, I135V, Y144F, E204D, H221Y, I293V, E297K  
>CA24551| codons 1-301
PISPIKTVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FVIRKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTILDVGDAYFSVPL
DEDFRKYTAFTIPSVNNKTPGIRFQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYIDDLYVASDLEIGQHRTKIEDLRQHLLRWGFTTPDKKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE
L

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A N88D I15V, E35D, M36I, N37D, L63P, A71V, V75I  
>CA24552| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYD
QIPIEICGHKVIGTILVGPTPANIIGRDLLTQIGCTLNF

References
Author Title Citation
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005