<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4423 CA24549 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 61
2 3TC+AZT 17
3 3TC+AZT+IDV 87
4 3TC+DDI+IDV 52
5 D4T+DDI+EFV+NFV 17
6 D4T+DLV+RTV+SQV 100

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215F K219Q K101E, Y181C, G190S   E6D, K20R, K49R, K64R, T69TN, V118I, D123E, I135T, T139K, I178L, T200S, H208Y, R211K, F214L, H221Y, L228LF, V245E  
>CA24549| codons 1-256
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIRKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
CQYMDDLYVSSDLEIGQHRSKIEELRQYLLKWGLFTPDQKYQKEPPFFWMGYELHPDKWT
VQPIELPEKDSWTVND

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I L24I, F53L, G73T L10I, I15V, G17E, K20R, E35D, M36I, R41K, K55R, I62V, L63P, A71AT, I72M  
>CA24550| codons 1-99
PQITLWQRPIVTIKVGEQLREALIDTGADDTVLEDINLPGKWKPKIIGGIGGLIRVRQYD
QVPIEICGHKTMTTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005