Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA642 | CA24542 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 52 |
| 2 | 3TC+D4T | 52 |
| 3 | 3TC+D4T+SQV | 48 |
| 4 | 3TC+D4T+NFV | 22 |
| 5 | 3TC+D4T+IDV+NVP | 17 |
| 6 | 3TC+D4T+DDI+RTV+SQV | 115 |
| 7 | Unknown | 86 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10LI, N37D, K55R, R57K, D60E, L63P, A71V, V77VI, I93L |
| >CA24542| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIRVKQYE QIPIEICGHKVISTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, M184V, T215F | K219Q | K43E, V75X, K122E, D123E, I142IV, S162A, D177E, G196E, H208Y, R211K, D218E, A272P, K277R, E297R |
| >CA24541| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKNSDRWRKIXDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIEELRQYLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTREAE |
References
| Author | Title | Citation |
| Winters, MA | Human immunodeficiency virus type 1 protease genotypes and in vitro protease inhibitor susceptibilities of isolates from individuals who were switched to other protease inhibitors after long-term saquinavir treatment. | J Virol, 1998 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |