<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA9928 CA24533 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 NVP+3TC+AZT 51

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, L74V, M184V K219KN Y181C   I31L, V35I, S68G, K122E, I135T, V179M, I202V, R211K, E291D  
>CA24533| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALIEICTEMEKEGKISKIGPENPYNTPV
FAIKRKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIMI
CQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFTTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVIPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I13V, E35D, N37S, R57K, L63P, I64V, V77I  
>CA24534| codons 1-99
PQITLWQRPLVSVKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVKQYD
QIPVEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Gonzales, MJ Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. AIDS, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005