Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1548 | CA24513 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 117 |
| 2 | AZT+ DDC | 108 |
| 3 | DDI | 95 |
| 4 | D4T | 30 |
| 5 | 3TC+ AZT | 39 |
| 6 | 3TC+ AZT+ IDV | 21 |
| 7 | 3TC+ D4T+ IDV | 12 |
| 8 | 3TC+ D4T+ NFV+ NVP | 21 |
| 9 | 3TC+ D4T+ NFV+ SQV | 39 |
| 10 | D4T+DDI+NFV+SQV | 148 |
| 11 | None | 9 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, T215Y | K219KE | K20R, T39TA, V60VI, K104N, D123E, S162C, I178M, V179I, T200A, E203ED, L228LH, A272T, I293IV |
| >CA24513| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRAKIDELRQHLLRWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYTGIKVKQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, E35D, L63P, I64V |
| >CA24514| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |