<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1548 CA24512 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 117
2 AZT+ DDC 108
3 DDI 95
4 D4T 30
5 3TC+ AZT 39
6 3TC+ AZT+ IDV 21
7 3TC+ D4T+ IDV 12
8 3TC+ D4T+ NFV+ NVP 21
9 3TC+ D4T+ NFV+ SQV 39
10 D4T+DDI+NFV+SQV 146

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L24I, K43T, F53L L10I, E35D, M36I, N37ND, I62V, L63P, I64V, G73V, T74S  
>CA24512| codons 1-98
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEDIDLPGRWTPKIIGGIGGLVKVRQYD
QVPVEICGHKAIVSVLVGPTPANIIGRNLLTQIGCTLN

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210LRW, T215Y K219E     K11R, K20R, V60I, V118I, D123E, S162Y, I178M, V179I, T200A, E203D, D218E, L228H, Q242H, I293V  
>CA24511| codons 1-301
PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDMII
YQYMDDLYVGSDLEIGQHRAKIDELRQHLWRWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
L

References
Author Title Citation
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005