Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5006 | CA24397 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 35 |
| 2 | 3TC+AZT+SQV | 65 |
| 3 | D4T+DDI+NFV | 81 |
| 4 | APV+D4T+EFV | 82 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | T215TI, K219Q | K101P, K103S | V60I, T69N, K102KR, K104KR, K122E, I135T, S162C, F214L, D218E, V245VA, A272P |
| >CA24397| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPRSRSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLITPEQKHQKEPPFLWMGYELHPDKWT VQPIALPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, L90LM | L33F, N88D | I13V, I15V, L19I, I62V, L63P |
| >CA24398| codons 1-98 PQITLWQRPLVTVKVGGQIKEALLDTGADDTVFEEMNLPGRWKPKMIGGIGGFLKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRDLMTQIGCTLN |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |