Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5299 | CA24378 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NVP | 52 |
| 2 | ABC+APV+D4T | 87 |
| 3 | 3TC+ABC+ADV+D4T | 22 |
| 4 | 3TC+APV+DLV | 37 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V | L33F, Q58E, L89V | I13V, I15V, L19I, E35D, N37S, R41K, L63P, A71T, I72V, V82I, I93L |
| >CA24378| codons 1-98 PQITLWQRPLVTVKVGGQIKEALLDTGADDTVFEDMSLPGKWKPKMIGGVGGFIKVREYD QIPIEICGHKTVGTVLVGPTPINIIGRNVLTQLGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | Y188L | S68G, D123E, I142V, S162N, T200A, R211NS, L228LH, E248D, A272P, K281R, L283I, I293V, E297A, G333E, R356K, A371V, A376T, T386A, K390R, A400T, K454R, V466A, V467VI, T497S, A554S |
| >CA24377| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRAKIEELRQHLLSWGFFTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLIRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGRAGYVTDRGRQKAISLTDTTNQKTELQ AIHLALQDSGLEVNIVSDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |