Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6405 | CA24329 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+DDC | 9 |
| 3 | 3TC+AZT | 22 |
| 4 | 3TC+AZT+IDV | 9 |
| 5 | 3TC+D4T+RTV | 174 |
| 6 | None | 10 |
| 7 | 3TC+D4T+NFV | 87 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L10F, N88D | I13V, I15V, N37T, R57K, L63P, I93L | Q18Q* |
| >CA24329| codons 1-99 PQITLWQRPFVTVKVGG*LKEALLDTGADNTVLEEMTLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLVGPTPVNIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K20R, V35IM, K43E, K104R, I135T, I202V, R211K, F214L, D250T |
| >CA24328| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLWKWGLYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKTSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE L |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |