Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6796 | CA24325 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 30 |
| 2 | D4T | 70 |
| 3 | 3TC+D4T+DDI+IDV | 65 |
| 4 | D4T+NFV+NVP | 28 |
| 5 | 3TC+D4T+IDV | 6 |
| 6 | 3TC+AZT+D4T+IDV | 18 |
| 7 | DDI+NFV+SQV | 34 |
| 8 | EFV+RTV+SQV | 9 |
| 9 | 3TC+APV+D4T | 9 |
| 10 | 3TC+APV+D4T+DDI | 20 |
| 11 | ABC+APV+RTV | 9 |
| 12 | 3TC+DDI+IDV | 21 |
| 13 | 3TC+D4T+DDI+LPV | 33 |
| 14 | APV+DDI+LPV | 23 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54IM, L76LV, I84V, L90M | V11VI, G73S, L89V | L10I, I13V, I15IV, Q18QH, K20I, M36I, R41RK, I62V, L63P, A71V |
| >CA24325| codons 1-98 PQITLWQRPIITVKVGGHLIEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFMKVRQYD QVPIEICGHKVISTVVVGPTPVNVIGRNVMTQIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | K219R | A98G | T39D, E44D, V118I, K122E, I142V, S162C, V179I, G196E, I202V, R211K, L228H, V245VEKM, A272AP, K281R, I293V, E297R |
| >CA24324| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICDELEKDGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIEQHRTKVEELRQHLWKWGFYTPDRKHQKEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTREA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |