<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4398 CA24311 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+DDC 25
2 3TC+D4T+IDV 72
3 3TC+D4T+RTV+SQV 76
4 APV+D4T+DDI+NVP+RTV 38
5 ABC+D4T+IDV+RTV 37
6 3TC+D4T+LPV 39

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   L10I, R41RK, K43KR, I62V, L63P, H69Y, A71T, I72E, V77VI, I93L  
>CA24311| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWRPKMIGGIGGFIKVRQYD
QVPIEICGYKTEGTVLIGPTPVNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74IV, L210W T215CG K103N, Y181YC   E6EK, S68G, K122E, I135IT, S162A, K173KE, I178M, Q207E, R211K, A272P, I293V  
>CA24310| codons 1-303
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFREQNPDMVI
CQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFCTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LEL

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005